Article

Pediatric pharmacogenomics from whole-exome sequencing: developmentally appropriate interpretation in 1,159 Russian children and newborns

2026-08-25

Abstract excerpt

<h4>Introduction: </h4> The application of pharmacogenomics (PGx) in pediatrics is limited by the lack of age-oriented interpretation approaches, as algorithms developed for adults do not account for ontogenetic changes in the activity of drug-metabolizing enzymes and transport proteins. The aim of this study was to evaluate the clinical applicability of pharmacogenomic data in Russian children, assess the concord...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2b1ac8f-af82-5a8d-b0fb-52907686a197
DOI: 10.64898/2026.08.21.26360945

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pediatric pharmacogenomics from whole-exome sequencing: developmentally appropriate interpretation in 1,159 Russian children and newbornsDOI 10.64898/2026.08.21.26360945Read

Pharmacogenomic Variants in the Russian Population: A Retrospective Analysis of 6102 ExomesSemantic proximity Read

Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives.Semantic proximity Read

Frequency and Implications of High-Risk Pharmacogenomic Phenotypes Identified in a Diverse Australian Pediatric Oncology Cohort.Semantic proximity Read

Pharmacogenomic biomarker information in FDA-approved paediatric drug labels.Semantic proximity Read

Retrospective Review of Pharmacogenetic Testing at an Academic Children’s HospitalSemantic proximity Read

Assessment of the Implementation of Pharmacogenomic Testing in a Pediatric Tertiary Care SettingSemantic proximity Read

Identifying genomic and developmental causes of adverse drug reactions in children.Semantic proximity Read

Genome sequencing as a platform for pharmacogenetic genotyping: a pediatric cohort studySemantic proximity Read

[Pharmacogenomics: precision tool in routine prescription].Semantic proximity Read

Adherence to International Pharmacogenomic Recommendations in Paediatric Cancer Care: A Cohort Analysis Embedded Within the MARVEL-PIC Randomised TrialSemantic proximity Read

Repurposing of Diagnostic Whole Exome Sequencing Data of 1,583 Individuals for Clinical PharmacogeneticsSemantic proximity Read

Should secondary pharmacogenomic variants be actively screened and reported when diagnostic genome-wide sequencing is performed in a child?Semantic proximity Read