Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-Based Dose Optimization in Children

8 Jul 2019

Abstract excerpt

Pharmacogenetics is a key component of precision medicine. Genetic variation in drug metabolism enzymes can lead to variable exposure to drugs and metabolites, potentially leading to inefficacy and drug toxicity. Although the evidence for pharmacogenetic associations in children is not as extensive as for adults, there are several drugs across diverse therapeutic areas with robust pediatric data indicating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics Pharmacokinetics and Efficacy
Share to Pharmaceutical studies and practices
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31283429
DOI: 10.1146/annurev-pharmtox-010919-023459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-Based Dose Optimization in ChildrenPMID 31283429Read ↗

Individualizing the use of medications in children: making Goldilocks happy.Semantic proximity Read ↗

Clinically relevant pharmacogenomic testing in pediatric practice.Semantic proximity Read ↗

Pharmacogenomics: the inherited basis for interindividual differences in drug response.Semantic proximity Read ↗

Clinical Pharmacogenetics and Potential Application in Personalized MedicineSemantic proximity Read ↗

Adherence to International Pharmacogenomic Recommendations in Paediatric Cancer Care: A Cohort Analysis Embedded Within the MARVEL-PIC Randomised TrialSemantic proximity Read ↗

Pharmacogenomics and Individualized Drug TherapySemantic proximity Read ↗

Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyondSemantic proximity Read ↗

[How to individualize drug therapy based on pharmacogenetic information? A systematic review of published guidelines].Semantic proximity Read ↗

Fundamentals of Pharmacogenetics in Personalized, Precision Medicine.Semantic proximity Read ↗

[Pharmacogenomics: precision tool in routine prescription].Semantic proximity Read ↗

Identifying genomic and developmental causes of adverse drug reactions in children.Semantic proximity Read ↗

Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.