Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome

2 May 2016

Abstract excerpt

UNLABELLED: In estrogen receptor (ER)-negative breast cancer, high tumor glucocorticoid receptor (GR) expression has been associated with a relatively poor outcome. In contrast, using a meta-analysis of several genomic datasets, here we find that tumor GR mRNA expression is associated with improved ER(+) relapse-free survival (RFS; independently of progesterone receptor expression). To understand the mechanism by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to FOXO transcription factor regulation
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27141101
DOI: 10.1158/1541-7786.mcr-15-0433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer OutcomePMID 27141101Read ↗

Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.Semantic proximity Read ↗

Glucocorticoid receptor regulates the EMT process through GR/ZEB1/E-cad and is involved in breast cancer endocrine drug resistanceSemantic proximity Read ↗

Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor α in endometrial cancerSemantic proximity Read ↗

Luminal breast cancer identity is determined by loss of glucocorticoid receptor activitySemantic proximity Read ↗

Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial CancerSemantic proximity Read ↗

STAT3 and GR cooperate to drive basal-like triple negative breast cancer gene expression and proliferationSemantic proximity Read ↗

ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancerSemantic proximity Read ↗

Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.Semantic proximity Read ↗

STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast CancerSemantic proximity Read ↗

Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signalingSemantic proximity Read ↗

The G-protein-coupled estrogen receptor, a gene co-expressed with ERα in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cellsSemantic proximity Read ↗

Glucocorticoid Receptor (GR) Expression in Human Tumors: A Tissue Microarray Study on More than 14,000 TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.