Article
Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
Breast cancer research : BCR - 24 Jul 2019
Tonsing-Carter Eva, Hernandez Kyle M, Kim Caroline R, Harkless Ryan V, Oh Alyce, Bowie Kathleen R, West-Szymanski Diana C, Betancourt-Ponce Mayra A, Green Bradley D, Lastra Ricardo R, Fleming Gini F, Chandarlapaty Sarat, Conzen Suzanne D
Abstract excerpt
BACKGROUND: Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-free survival in ER+ breast cancer (BC) patients. METHODS: In vitro cell proliferation assays were used to assess ER-mediated BC cell...
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