Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during <i>Staphylococcus aureus</i> infection

Abstract excerpt

A hallmark of Staphylococcus aureus disease in humans is persistent infections without development of protective immune responses. Infected patients generate VH3 plasmablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal modification of immune responses are not known. We report here that S. aureus-infected mice generate VH3 antibody expansions via a mechanism requiring...

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