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Article

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites.

Structure (London, England : 1993) - 7 Jun 2016

Simon Bertrand, Huart Anne-Sophie, Temmerman Koen, Vahokoski Juha, Mertens Haydyn D T, Komadina Dana, Hoffmann Jan-Erik, Yumerefendi Hayretin, Svergun Dmitri I, Kursula Petri, Schultz Carsten, McCarthy Andrew A, Hart Darren J, Wilmanns Matthias

Abstract excerpt

The regulation of many protein kinases by binding to calcium/calmodulin connects two principal mechanisms in signaling processes: protein phosphorylation and responses to dose- and time-dependent calcium signals. We used the calcium/calmodulin-dependent members of the death-associated protein kinase (DAPK) family to investigate the role of a basic DAPK signature loop near the kinase active site. In DAPK2, this...

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Identifiers

PMID: 27133022
DOI: 10.1016/j.str.2016.03.020
PMCID: PMC4906247

Genes

DAPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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