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Article

cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2.

Biochemical and biophysical research communications - 1 Jun 2012

Isshiki Kinuka, Matsuda Shinya, Tsuji Akihiko, Yuasa Keizo

Abstract excerpt

cGMP-dependent protein kinase-I (cGK-I) induces apoptosis in various cancer cell lines. However, the signaling mechanisms involved remain unknown. Using protein microarray technology, we identified a novel cGK substrate, death-associated protein kinase 2 (DAPK2), which is a Ca(2+)/calmodulin-regulated serine/threonine kinase. cGK-I phosphorylated DAPK2 at Ser(299), Ser(367) and Ser(368). Interestingly, a...

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Source

Identifiers

PMID: 22580283
DOI: 10.1016/j.bbrc.2012.04.148

Genes

DAPK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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