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Article

TACE-dependent TGFα shedding drives triple-negative breast cancer cell invasion.

International journal of cancer - 1 Dec 2013

Giricz Orsi, Calvo Veronica, Peterson Esther A, Abouzeid Christiane M, Kenny Paraic A

Abstract excerpt

The epidermal growth factor receptor (EGFR) is frequently expressed in triple-negative breast cancer (TNBC) and is a marker of poor prognosis in this patient population. Because activating mutations in this kinase are very rare events in breast cancer, we screened breast tumor gene expression profiles to examine the distribution of EGFR ligand expression. Of the six known EGFR ligands, transforming growth factor...

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Identifiers

PMID: 23729230
DOI: 10.1002/ijc.28295
PMCID: PMC3966141

Genes

EGFR
ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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