Article
Mitochondria-targeted hydrogen sulfide donor reduces atherogenesis by changing macrophage phenotypes and increasing UCP1 expression in vascular smooth muscle cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2024
Stachowicz Aneta, Wiśniewska Anna, Czepiel Klaudia, Pomierny Bartosz, Skórkowska Alicja, Kuśnierz-Cabala Beata, Surmiak Marcin, Kuś Katarzyna, Wood Mark E, Torregrossa Roberta, Whiteman Matthew, Olszanecki Rafał
Abstract excerpt
Atherosclerosis is a leading cause of morbidity and mortality in the Western countries. Mounting evidence points to the role of mitochondrial dysfunction in the pathogenesis of atherosclerosis. Recently, it has been shown that mitochondrial hydrogen sulfide (H2S) can complement the bioenergetic role of Krebs cycle leading to improved mitochondrial function. However, controlled, direct delivery of H2S to...
Topics
Join the communities discussing this publication.