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Article

Identification of Factors Affecting the Success of Next-Generation Sequencing Testing in Solid Tumors.

American journal of clinical pathology - 1 Feb 2016

Goswami Rashmi S, Luthra Rajyalakshmi, Singh Rajesh R, Patel Keyur P, Routbort Mark J, Aldape Kenneth D, Yao Hui, Dang Hyvan D, Barkoh Bedia A, Manekia Jawad, Medeiros L Jeffrey, Roy-Chowdhuri Sinchita, Stewart John, Broaddus Russell R, Chen Hui

Abstract excerpt

OBJECTIVES: Clinical laboratories are rapidly implementing next-generation sequencing (NGS) tests for mutation analysis, but there are few guidelines regarding sample quality for successful results. METHODS: We aimed to establish tissue quality parameters for successful NGS in solid tumors and to improve NGS performance. RESULTS: Analysis of 614 clinical cases tested in 2013 using a 50-gene hotspot mutation panel...

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PMID: 27124905
DOI: 10.1093/ajcp/aqv023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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