Article
Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma.
Oncotarget - 24 May 2016
Lupini Laura, Pepe Felice, Ferracin Manuela, Braconi Chiara, Callegari Elisa, Pagotto Sara, Spizzo Riccardo, Zagatti Barbara, Lanuti Paola, Fornari Francesca, Ghasemi Reza, Mariani-Costantini Renato, Bolondi Luigi, Gramantieri Laura, Calin George A, Sabbioni Silvia, Visone Rosa, Veronese Angelo, Negrini Massimo
Abstract excerpt
The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in HCC cells carrying wild-type TP53 the steady activation of the miR-145 signaling selects clones resistant to apoptosis via up-regulation of the oncogenic miR-483-3p. Expression of the miR-145-5p...
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