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Article

FET proteins regulate lifespan and neuronal integrity.

Scientific reports - 27 Apr 2016

Therrien Martine, Rouleau Guy A, Dion Patrick A, Parker J Alex

Abstract excerpt

The FET protein family includes FUS, EWS and TAF15 proteins, all of which have been linked to amyotrophic lateral sclerosis, a fatal neurodegenerative disease affecting motor neurons. Here, we show that a reduction of FET proteins in the nematode Caenorhabditis elegans causes synaptic dysfunction accompanied by impaired motor phenotypes. FET proteins are also involved in the regulation of lifespan and stress...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27117089
DOI: 10.1038/srep25159
PMCID: PMC4846834

Genes

FUS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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FET proteins regulate lifespan and neuronal integrity.PMID 27117089Read ↗

Role of FET proteins in neurodegenerative disorders.Semantic proximity Read ↗

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FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilizationSemantic proximity Read ↗

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant FunctionsSemantic proximity Read ↗

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegansSemantic proximity Read ↗

Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

FUS-related proteinopathies: Lessons from animal modelsSemantic proximity Read ↗

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