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The <i>HOTAIRM1-miR-222</i> Axis Regulates Venetoclax Resistance and Defines a High-Risk Subset in Pediatric t(8;21) Acute Myeloid Leukemia

2025-07-17

Abstract excerpt

Although acute myeloid leukemia (AML) with the RUNX1::RUNX1T1 fusion [t(8;21)(q22;q22.1)] defines a distinct cytogenetic subtype, differences in treatment response suggest additional molecular contributors beyond chromosomal abnormalities. Deregulated hematopoietic lineage-specific long non-coding RNAs (lncRNAs) contribute to leukemogenesis and therapy resistance. To investigate their role in t(8;21) AML, we perf...

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Literature Corpus work
2d5b042a-1ed6-5ee0-aa32-a11e93ca5ea6
DOI
10.1101/2025.07.12.663834
Open publication

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The <i>HOTAIRM1-miR-222</i> Axis Regulates Venetoclax Resistance and Defines a High-Risk Subset in Pediatric t(8;21) Acute Myeloid LeukemiaDOI 10.1101/2025.07.12.663834
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