Article
A W-test collapsing method for rare-variant association testing in exome sequencing data.
Genetic epidemiology - 1 Nov 2016
Sun Rui, Weng Haoyi, Hu Inchi, Guo Junfeng, Wu William K K, Zee Benny Chung-Ying, Wang Maggie Haitian
Abstract excerpt
Advancement in sequencing technology enables the study of association between complex disorder phenotypes and single-nucleotide polymorphisms with rare mutations. However, the rare genetic variant has extremely small variance and impairs testing power of traditional statistical methods. We introduce a W-test collapsing method to evaluate rare-variant association by measuring the distributional differences between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.