Article
Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype.
Scientific reports - 26 Apr 2016
Daxinger Lucia, Oey Harald, Isbel Luke, Whitelaw Nadia C, Youngson Neil A, Spurling Alex, Vonk Kelly K D, Whitelaw Emma
Abstract excerpt
The number of reports of paternal epigenetic influences on the phenotype of offspring in rodents is increasing but the molecular events involved remain unclear. Here, we show that haploinsufficiency for the histone 3 lysine 9 methyltransferase Setdb1 in the sire can influence the coat colour phenotype of wild type offspring. This effect occurs when the allele that directly drives coat colour is inherited from the...
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