Article
HIV-1 Mutation and Recombination Rates Are Different in Macrophages and T-cells.
Viruses - 22 Apr 2016
Cromer Deborah, Schlub Timothy E, Smyth Redmond P, Grimm Andrew J, Chopra Abha, Mallal Simon, Davenport Miles P, Mak Johnson
Abstract excerpt
High rates of mutation and recombination help human immunodeficiency virus (HIV) to evade the immune system and develop resistance to antiretroviral therapy. Macrophages and T-cells are the natural target cells of HIV-1 infection. A consensus has not been reached as to whether HIV replication results in differential recombination between primary T-cells and macrophages. Here, we used HIV with silent mutation...
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