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Article

High co-expression of PD-L1 and HIF-1α correlates with tumour necrosis in pulmonary pleomorphic carcinoma.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2016

Chang Yih-Leong, Yang Ching-Yao, Lin Mong-Wei, Wu Chen-Tu, Yang Pan-Chyr

Abstract excerpt

BACKGROUND: Pulmonary pleomorphic carcinomas (PPCs) are uncommon malignant tumours characterised by an aggressive clinical course and poor survival. These neoplasms frequently exhibit marked confluent necrosis, in which hypoxia levels are extremely high, causing low responsiveness to chemotherapy and conferring basic resistance to anti-cancer drugs. Programmed death ligand 1 (PD-L1)-mediated immune escape may be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27107327
DOI: 10.1016/j.ejca.2016.03.012

Genes

EGFR
ROS1
ALK
BRAF
KRAS
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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