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Article

Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2016

Vieira Thibault, Antoine Martine, Hamard Cécile, Fallet Vincent, Duruisseaux Michael, Rabbe Nathalie, Rodenas Anita, Cadranel Jacques, Wislez Marie

Abstract excerpt

OBJECTIVES: Pulmonary sarcomatoid carcinomas (SC) are rare tumors, associated with worse prognosis and resistant to platinum-based regimens. Therapies targeting the PD-1/PD-L1 pathway are an emerging treatment for lung cancer. By characterizing intra-tumoral immune infiltration and evaluating PD-L1 expression, it could be possible to predict the efficacy of these new treatments. MATERIALS AND METHODS: From 1997...

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Identifiers

PMID: 27393506
DOI: 10.1016/j.lungcan.2016.05.013

Genes

KRAS
MPO
TTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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