Article
Mutational analysis of JAK2, CBL, RUNX1, and NPM1 genes in familial aggregation of hematological malignancies.
Annals of hematology - 1 Jun 2016
Hamadou Walid S, Bourdon Violaine, Gaildrat Pascaline, Besbes Sawsen, Fabre Aurélie, Youssef Yosra B, Regaieg Haifa, Laatiri Mohamed A, Eisinger François, Mari Véronique, Gesta Paul, Dreyfus Hélène, Bonadona Valérie, Dugast Catherine, Zattara Hélène, Faivre Laurence, Jemni Saloua Yacoub, Noguchi Testsuro, Khélif Abderrahim, Sobol Hagay, Soua Zohra
Abstract excerpt
Familial aggregation of hematological malignancies has been reported highlighting inherited genetic predisposition. In this study, we targeted four candidate genes: JAK2 and RUNX1 genes assuring a prominent function in hematological process and CBL and NPM1 as proto-oncogenes. Their disruption was described in several sporadic hematological malignancies. The aim of this study is to determine whether JAK2, CBL,...
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