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Article

SRPK1 and Akt Protein Kinases Phosphorylate the RS Domain of Lamin B Receptor with Distinct Specificity: A Combined Biochemical and In Silico Approach.

PloS one - 1 Jan 2016

Voukkalis Nikolaos, Koutroumani Maria, Zarkadas Christoforos, Nikolakaki Eleni, Vlassi Metaxia, Giannakouros Thomas

Abstract excerpt

Activated Akt has been previously implicated in acting on RS domain-containing proteins. However, it has been questioned whether its action is direct or it is mediated by co-existing SR kinase activity. To address this issue we studied in detail the phosphorylation of Lamin B Receptor (LBR) by Akt. Using synthetic peptides and a set of recombinant proteins expressing mutants of the LBR RS domain we now...

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Source

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Identifiers

PMID: 27105349
DOI: 10.1371/journal.pone.0154198
PMCID: PMC4841541

Genes

LBR
SRPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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