Article
Association of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes.
Diabetes/metabolism research and reviews - 1 May 2017
Ziegler Dan, Schleicher Erwin, Strom Alexander, Knebel Birgit, Fleming Thomas, Nawroth Peter, Häring Hans-Ulrich, Papanas Nikolaos, Szendrödi Julia, Müssig Karsten, Al-Hasani Hadi, Roden Michael
Abstract excerpt
BACKGROUND: Shunting of glycolytic intermediates into the pentose phosphate pathway has been suggested to protect from hyperglycaemia-induced microvascular damage. We hypothesized that genetic variability in the gene encoding transketolase, a key pentose phosphate pathway enzyme, contributes to early nerve dysfunction in recent-onset diabetes. METHODS: In this cross-sectional study, we assessed nine single...
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