Article
Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality.
Clinical chemistry and laboratory medicine - 1 Jan 2014
Tanhäuserová Veronika, Kuricová Katarína, Pácal Lukáš, Bartáková Vendula, Rehořová Jitka, Svojanovský Jan, Olšovský Jindřich, Bělobrádková Jana, Kaňková Kateřina
Abstract excerpt
BACKGROUND: We hypothesized that genetic variability in genes encoding enzymes metabolizing glycolytic intermediates produced in excess under hyperglycemic conditions [i.e., transketolase (TKT), transaldolase, TKT-like protein 1, fructosamine 3-kinase (FN3K), glyoxalase 1 and glucose-6-phosphate dehydrogenase] could influence progression of diabetic nephropathy (DN) and diabetes-related morbidity and mortality....
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