Peripheral pain threshold, glycaemic status, and LAMP3 genetic variation: A community-based analysis.

doi:10.1016/j.nbd.2026.107546

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Article

Peripheral pain threshold, glycaemic status, and LAMP3 genetic variation: A community-based analysis.

Neurobiology of disease - 1 Oct 2026

Ruike Hidefumi, Mizukami Hiroki, Wang Zhenchao, Kushibiki Hanae, Ishida Mizuri, Osonoi Sho, Tarusawa Takefusa, Sasaki Takanori, Yi Tu, Ogasawara Saori, Itaya Akiko, Abe Atsumi, Kumagai Gentaro, Tamada Yoshinori, Fujita Yukihiro, Mikami Tatsuya, Itoh Ken, Ishibashi Yasuyuki, Hakamada Kenichi, Murashita Koich, Nakaji Shigeyuki

Abstract excerpt

Diabetic polyneuropathy is a common complication of diabetes, yet substantial inter-individual variation in peripheral pain perception suggests underlying genetic influences. This population-based study investigated clinical, metabolic, and genetic determinants of pain threshold using intraepidermal electrical stimulation in 906 participants from the Iwaki Health Promotion Project 2017. Genome-wide association...

Read the complete abstract on PubMed

Topics

Humans
Male
Female
Diabetic Neuropathies
Pain Threshold

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Lysosomal-Associated Membrane Protein 3

Middle Aged

Polymorphism, Single Nucleotide

Blood Glucose

Genetic Variation

Aged

Genotype

Neoplasm Proteins

Source

Open in PubMed

Identifiers

PMID: 42508734
DOI: 10.1016/j.nbd.2026.107546

Genes

LAMP3
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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