Article
Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Apr 2011
Pácal Lukás, Tomandl Josef, Svojanovsky Jan, Krusová Darja, Stepánková Sona, Rehorová Jitka, Olsovsky Jindrich, Belobrádková Jana, Tanhäuserová Veronika, Tomandlová Marie, Muzík Jan, Kanková Katerina
Abstract excerpt
BACKGROUND: Pentose phosphate pathway (PPP) represents a potentially 'protective' mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP enzymes-transketolase (TKT), transaldolase and TKT-like-might contribute to the progression of...
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