Article
P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E-Deficient Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016
Zhang Nan, Liu Zhenghui, Yao Longbiao, Mehta-D'souza Padmaja, McEver Rodger P
Abstract excerpt
OBJECTIVE: During inflammation, P-selectin expressed on activated endothelial cells and platelets mediates rolling adhesion of leukocytes. Atherosclerosis-prone mice crossed with P-selectin-deficient (Selp(-/-)) mice develop smaller lesions. Cytokines, such as tumor necrosis factor-α, increase Se...
Topics
- Animals
- Aorta
- Aortic Diseases
- Apolipoproteins E
- Atherosclerosis
- Blood Platelets
- Bone Marrow Transplantation
- Diet, High-Fat
- Disease Models, Animal
- Disease Progression
- Endothelial Cells
- Genetic Predisposition to Disease
- Humans
- Macrophages
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- P-Selectin