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Article

P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E-Deficient Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Zhang Nan, Liu Zhenghui, Yao Longbiao, Mehta-D'souza Padmaja, McEver Rodger P

Abstract excerpt

OBJECTIVE: During inflammation, P-selectin expressed on activated endothelial cells and platelets mediates rolling adhesion of leukocytes. Atherosclerosis-prone mice crossed with P-selectin-deficient (Selp(-/-)) mice develop smaller lesions. Cytokines, such as tumor necrosis factor-α, increase Selp transcripts and augment atherosclerosis in mice. However, they decrease SELP transcripts in humans, challenging...

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Source

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Identifiers

PMID: 27102967
DOI: 10.1161/ATVBAHA.116.307437
PMCID: PMC4882243

Genes

SELP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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