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Article

Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2004

Teckman Jeffrey H, An Jae-Koo, Blomenkamp Keith, Schmidt Bela, Perlmutter David

Abstract excerpt

Homozygous, PIZZ alpha(1)-antitrypsin (alpha(1)-AT) deficiency is associated with chronic liver disease and hepatocellular carcinoma resulting from the toxic effects of mutant alpha(1)-anti-trypsin Z (alpha(1)-ATZ) protein retained in the endoplasmic reticulum (ER) of hepatocytes. However, the exact mechanism(s) by which retention of this aggregated mutant protein leads to cellular injury are still unknown....

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Identifiers

PMID: 14684378
DOI: 10.1152/ajpgi.00175.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency.PMID 14684378Read ↗

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