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Article

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region

3 Dec 2008

Abstract excerpt

The primary cilium is an antenna-like structure extending from the surface of most vertebrate cells. Loss or mutation of ciliary proteins can lead to polycystic kidney disease and other developmental abnormalities. inv mutant mice develop multiple renal cysts and are a model for human nephronophthisis type 2. The mouse Inv gene encodes a 1062-amino-acid protein that is localized in primary cilia. In this study,...

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PMID: 19050042
DOI: 10.1242/jcs.037408

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing regionPMID 19050042Read ↗

Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary ciliaSemantic proximity Read ↗

Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice.Semantic proximity Read ↗

The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6.Semantic proximity Read ↗

Functions and trafficking mechanisms of RIC-8 in <i>C. elegans</i> and mammalian ciliaSemantic proximity Read ↗

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119Semantic proximity Read ↗

Novel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy.Semantic proximity Read ↗

Renal cysts of inv/inv mice resemble early infantile nephronophthisis.Semantic proximity Read ↗

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.Semantic proximity Read ↗

Cystin Localizes to Primary Cilia via Membrane Microdomains and a Targeting MotifSemantic proximity Read ↗

Tmem138, a photoreceptor connecting cilium (CC) protein, is required for rhodopsin transport across the cilium and outer segment (OS) biogenesisSemantic proximity Read ↗

The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.Semantic proximity Read ↗

Compartments within a compartmentSemantic proximity Read ↗

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