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Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy

23 Aug 2023

Abstract excerpt

ABC transporters are ubiquitous in the human body and are responsible for the efflux of drugs. They are present in the placenta, intestine, liver and kidney, which are the major organs that can affect the pharmacokinetic and pharmacologic properties of drugs. P-gp and BCRP transporters are the best-characterized transporters in the ABC superfamily, and they have a pivotal role in the barrier tissues due to their...

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PMID: 37685897
DOI: 10.3390/ijms241713089

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