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Article

Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301.

PloS one - 1 Jan 2016

Chopra Avijeet, Bond Michael J, Bleiler Marina, Yeagley Michelle, Wright Dennis, Giardina Charles

Abstract excerpt

Mitotic inhibitors are widely utilized chemotherapeutic agents that take advantage of mitotic defects in cancer cells. We have identified a novel class of piperazine-based mitotic inhibitors, of which AK301 is the most potent derivative identified to date (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release....

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Identifiers

PMID: 27097159
DOI: 10.1371/journal.pone.0153818
PMCID: PMC4838221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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