Article
Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation.
PloS one - 1 Jan 2013
Hermant Bastien, Herman Bastien, Gudrun Aldrian, Potopalsky Anatoly I, Chroboczek Jadwiga, Tcherniuk Sergey O
Abstract excerpt
Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine (Chelidonium majus L.) alkaloids with the organophosphorous compound N,N'N'-triethylenethiophosphoramide (ThioTEPA). We show here that the treatment of living cells with Am reversibly perturbs the microtubule cytoskeleton, provoking a dose-dependent cell arrest in the M phase. Am changed the dynamics of tubulin polymerization in...
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