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An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe

18 Feb 2010

Abstract excerpt

Mitotic catastrophe can be defined as a cell death mode that occurs during or shortly after a prolonged/aberrant mitosis, and can show apoptotic or necrotic features. However, conventional procedures for the detection of apoptosis or necrosis, including biochemical bulk assays and cytofluorometric techniques, cannot discriminate among pre-mitotic, mitotic and post-mitotic death, and hence are inappropriate to...

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PMID: 21364633
DOI: 10.1038/cddis.2010.6

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