Article
Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma.
Biology direct - 26 Jun 2026
Zhu Ningqi, Zhang Guo, Shen Xiaotian, Chen Zule, Li Ying, Chen Diyu, Jia Huliang
Abstract excerpt
BACKGROUND: Mutations in CTNNB1 are recognized oncogenic drivers of hepatocellular carcinoma (HCC); however, the downstream effector molecules and their prognostic significance remain incompletely defined. In this study, we developed a mutant CTNNB1 gene signature (MCGS) to predict CTNNB1 mutation status and to evaluate the prognostic relevance of the constituent genes. METHODS: Hydrodynamic tail vein injection...
Read the complete abstract on PubMedTopics
- beta Catenin
- Carcinoma, Hepatocellular
- Animals
- Liver Neoplasms
- Mice
- Prognosis
- Mutation