Article
Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.
Journal of cancer research and clinical oncology - 1 Jul 2016
Yoshida Kazuhiro, Nagasaka Takeshi, Umeda Yuzo, Tanaka Takehiro, Kimura Keisuke, Taniguchi Fumitaka, Fuji Tomokazu, Shigeyasu Kunitoshi, Mori Yoshiko, Yanai Hiroyuki, Yagi Takahito, Goel Ajay, Fujiwara Toshiyoshi
Abstract excerpt
PURPOSE: Although limited understanding exists for the presence of specific genetic mutations and aberrantly methylated genes in pancreatobiliary intraductal papillary mucinous neoplasms (IPMNs), the fundamental understanding of the dynamics of methylation expansion across CpG dinucleotides in specific gene promoters during carcinogenesis remains unexplored. Expansion of DNA methylation in some gene promoter...
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