Article
Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD.
Scientific reports - 14 Oct 2015
Woo Yu Mi, Shin Yubin, Hwang Jung-Ah, Hwang Young-Hwan, Lee Sunyoung, Park Eun Young, Kong Hyun Kyung, Park Hayne Cho, Lee Yeon-Su, Park Jong Hoon
Abstract excerpt
Although autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease, and is characterized by the formation of multiple fluid-filled cysts, which results in renal failure, early diagnosis and treatment of ADPKD have yet to be defined. Herein, we observed that the promoter region of the gene encoding mucin-like protocadherin (MUPCDH) was hypermethylated in the renal tissue of patients with...
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