Article
Single nucleotide polymorphism rs3732860 in the 3'-untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese.
Journal of gastroenterology and hepatology - 1 Apr 2013
Qin Jian, Han Tian-Quan, Yuan Wen-Tao, Zhang Jing, Fei Jian, Jiang Zhao-Yan, Niu Zhen-Min, Zhang Kai-Yue, Hua Qi, Cai Xing-Xing, Xu Shi-Jie, Huang Wei, Zhang Sheng-Dao
Abstract excerpt
BACKGROUND AND AIMS: Gallstone disease (GD) is a common disease of multigenetic origin; however, the major susceptibility loci for GD in human populations remain unidentified. This study aimed to identify the genetic factors contributing to gallstone development in Chinese. METHODS: A genome-wide scan was conducted in 12 Han Chinese GD families to identify linkage loci. The linkage region showing the highest...
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