Article
NMR identification of the binding surfaces involved in the Salmonella and Shigella Type III secretion tip-translocon protein-protein interactions.
Proteins - 1 Aug 2016
McShan Andrew C, Kaur Kawaljit, Chatterjee Srirupa, Knight Kevin M, De Guzman Roberto N
Abstract excerpt
The type III secretion system (T3SS) is essential for the pathogenesis of many bacteria including Salmonella and Shigella, which together are responsible for millions of deaths worldwide each year. The structural component of the T3SS consists of the needle apparatus, which is assembled in part by the protein-protein interaction between the tip and the translocon. The atomic detail of the interaction between the...
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