Article
Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System.
PloS one - 1 Jan 2016
Cheung Ka-Wai, Peng Qiaoli, He Liufen, Cai Kanru, Jiang Qiang, Zhou Boping, To Sabrina Wai-Chi, Yam Wing-Cheong, Liu Li, Chen Zhiwei, Wang Hui
Abstract excerpt
The development of a rapid, high-throughput and cost-effective HIV-1 drug resistance (HIV-DR) testing system is a challenge for areas consisting different HIV-1 strains. In this study, we established a broadly reactive multiplex assay that could simultaneously detect major drug resistance mutations at 8 loci, which are associated with resistance to commonly used nucleoside reverse transcriptase inhibitors (NRTIs)...
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