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Article

Autophagy facilitates organelle clearance during differentiation of human erythroblasts

31 May 2013

Abstract excerpt

Wholesale depletion of membrane organelles and extrusion of the nucleus are hallmarks of mammalian erythropoiesis. Using quantitative EM and fluorescence imaging we have investigated how autophagy contributes to organelle removal in an ex vivo model of human erythroid differentiation. We found that autophagy is induced at the polychromatic erythroid stage, and that autophagosomes remain abundant until...

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PMID: 23508006
DOI: 10.4161/auto.24172

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