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Hierarchal Autophagic Divergence of Hematopoietic System

6 Aug 2015

Abstract excerpt

Autophagy is integral to hematopoiesis and protects against leukemogenesis. However, the fundamentals of the required molecular machinery have yet to be fully explored. Using conditional mouse models to create strategic defects in the hematopoietic hierarchy, we have shown that recovery capacities in stem cells and somatic cells differ if autophagy is impaired or flawed. An in vivo Atg7 deletion in hematopoietic...

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PMID: 26245898
DOI: 10.1074/jbc.m115.650028

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