Article
The complement component 5 gene and age-related macular degeneration.
Ophthalmology - 1 Mar 2010
Baas Dominique C, Ho Lintje, Ennis Sarah, Merriam Joanna E, Tanck Michael W T, Uitterlinden André G, de Jong Paulus T V M, Cree Angela J, Griffiths Helen L, Rivadeneira Fernando, Hofman Albert, van Duijn Cornelia, Smith R Theodore, Barile Gaetano R, Gorgels Theo G M F, Vingerling Johannes R, Klaver Caroline C W, Lotery Andrew J, Allikmets Rando, Bergen Arthur A B
Abstract excerpt
OBJECTIVE: To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD). DESIGN: Separate and combined data from 3 large AMD case-control studies and a prospective population-based study (The Rotterdam Study). PARTICIPANTS: A total of 2599 AMD cases and 3458 ethnically matched controls. METHODS: Fifteen single nucleotide polymorphisms (SNPs)...
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