Article
Complement factor D in age-related macular degeneration.
Investigative ophthalmology & visual science - 11 Nov 2011
Stanton Chloe M, Yates John R W, den Hollander Anneke I, Seddon Johanna M, Swaroop Anand, Stambolian Dwight, Fauser Sascha, Hoyng Carel, Yu Yi, Atsuhiro Kanda, Branham Kari, Othman Mohammad, Chen Wei, Kortvely Elod, Chalmers Kevin, Hayward Caroline, Moore Anthony T, Dhillon Baljean, Ueffing Marius, Wright Alan F
Abstract excerpt
PURPOSE: To examine the role of complement factor D (CFD) in age-related macular degeneration (AMD) by analysis of genetic association, copy number variation, and plasma CFD concentrations. METHODS: Single nucleotide polymorphisms (SNPs) in the CFD gene were genotyped and the results analyzed by binary logistic regression. CFD gene copy number was analyzed by gene copy number assay. Plasma CFD was measured by an...
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