Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors.

Cancer letters - 1 Jul 2016

Boublikova L, Bakardjieva-Mihaylova V, Skvarova Kramarzova K, Kuzilkova D, Dobiasova A, Fiser K, Stuchly J, Kotrova M, Buchler T, Dusek P, Grega M, Rosova B, Vernerova Z, Klezl P, Pesl M, Zachoval R, Krolupper M, Kubecova M, Stahalova V, Abrahamova J, Babjuk M, Kodet R, Trka J

Abstract excerpt

PURPOSE: Wilms tumor gene 1 (WT1), a zinc-finger transcription factor essential for testis development and function, along with other genes, was investigated for their role in the pathogenesis of testicular germ cell tumors (TGCT). METHODS: In total, 284 TGCT and 100 control samples were investigated, including qPCR for WT1 expression and BRAF mutation, p53 immunohistochemistry detection, and massively parallel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Feasibility Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Neoplasms, Germ Cell and Embryonal

Share to Proto-Oncogene Proteins c-kit

Share to Real-Time Polymerase Chain Reaction

Share to Testicular Neoplasms

Share to WT1 Proteins

Source

Identifiers

PMID: 27085458
DOI: 10.1016/j.canlet.2016.04.016

Genes

BRAF
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors.PMID 27085458Read ↗

Genetics of testicular germ cell tumorsSemantic proximity Read ↗

Comprehensive characterization of cancer‐testis genes in testicular germ cell tumorSemantic proximity Read ↗

Wilms’ Tumor GeneWT1: Its Oncogenic Function and Clinical ApplicationSemantic proximity Read ↗

The Epigenetics of Testicular Germ Cell Tumors: Looking for Novel Disease BiomarkersSemantic proximity Read ↗

Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapySemantic proximity Read ↗

Testicular germ cell tumor genomics.Semantic proximity Read ↗

The testicular germ cell tumour transcriptomeSemantic proximity Read ↗

Germ cell tumour subtypes display differential expression of microRNA371a-3pSemantic proximity Read ↗

Wilms' tumor gene 1 in hematological malignancies: friend or foe?Semantic proximity Read ↗

Comprehensive characteristics of pathological subtypes in testicular germ cell tumor: Gene expression, mutation and alternative splicing.Semantic proximity Read ↗

Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors: results of long-term surveillance of 71 patients from International Society of Pediatric Oncology Study 9/Society for Pediatric Oncology.Semantic proximity Read ↗

The role of the Wilms tumour gene (<i>WT1</i>) in normal and malignant haematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.