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Article

Regulatory network structure determines patterns of intermolecular epistasis.

eLife - 13 Nov 2017

Lagator Mato, Sarikas Srdjan, Acar Hande, Bollback Jonathan P, Guet Călin C

Abstract excerpt

Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how the distribution of mutational effects of a transcriptional regulatory system differs from the distributions of its components, by first independently, and then...

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Identifiers

PMID: 29130883
DOI: 10.7554/eLife.28921
PMCID: PMC5699867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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