Genetic association of NAD(P)H quinone oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy.

doi:10.1515/hsz-2016-0135

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Article

Genetic association of NAD(P)H quinone oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy.

Biological chemistry - 1 Aug 2016

Sharma Mohini, Mehndiratta Mohit, Gupta Stuti, Kalra Om P, Shukla Rimi, Gambhir Jasvinder K

Abstract excerpt

NAD(P)H quinone oxidoreductase 1 (NQO1) catalyzes reactions having a cyto-protective effect against redox cycling and oxidative stress. A single base polymorphism (C/T) at nucleotide 609 of the NQO1 gene impairs the stability and function of its protein. Its role in the development of diabetic nephropathy (DN) has not been deciphered. Therefore, this study aimed to evaluate the association of NQO1*2 (rs1800566)...

Topics

Adult
Alleles
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Enzyme-Linked Immunosorbent Assay
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

India

Logistic Models

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

Polymorphism, Genetic

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 27078674
DOI: 10.1515/hsz-2016-0135

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27078674-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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