Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population.

doi:10.1089/rej.2024.0032

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Article

Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population.

Rejuvenation research - 1 Oct 2024

Alhaji Jwaher Haji, Pathak Divya, Ashfaq Fauzia, Alsayegh Abdulrahman A, Khatoon Fahmida, Almutairi Bader Judaya, Khan Mohammad Idreesh, Beg Mirza Masroor Ali

Abstract excerpt

NQO1 disruption enhances susceptibility to oxidative stress during hyperglycemia and is a significant contributor to the development and progression of diabetes. Oxidative stress has been linked to several symptoms, including hyperglycemia, reactive oxygen species buildup, high blood pressure, and the expression of inflammatory markers. Therefore, the present research aimed to evaluate the genetic abnormality of...

Topics

Humans
NAD(P)H Dehydrogenase (Quinone)
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Male
Female
Saudi Arabia
Middle Aged
Polymorphism, Single Nucleotide
Case-Control Studies
Vitamin D
Adult
RNA, Messenger
Gene Frequency
Genotype

Source

Open in PubMed

Identifiers

PMID: 38959119
DOI: 10.1089/rej.2024.0032

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