Article
An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin.
PloS one - 1 Jan 2013
Ramachandran Gayatri, Kumar Manoj, Selvi Rani Deepa, Annanthapur Venkateshwari, Calambur Narasimhan, Nallari Pratibha, Kaur Punit
Abstract excerpt
Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD). Several sarcomeric proteins and modifier genes have been implicated in this disease. Troponin I, being a part of the Troponin complex (troponin I, troponin C, troponin T), is an important gene for sarcomeric function. Four...
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