Article
A common variation of the PTEN gene is associated with peripheral insulin resistance.
Diabetes & metabolism - 1 Sept 2016
Grinder-Hansen L, Ribel-Madsen R, Wojtaszewski J F P, Poulsen P, Grunnet L G, Vaag A
Abstract excerpt
AIM: Phosphatase and tensin homologue (PTEN) reduces insulin sensitivity by inhibiting the phosphatidylinositol 3-kinase (PI3K)/v-akt murine thymoma viral oncogene homologue (Akt) pathway. This study investigated how a common single nucleotide polymorphism near PTEN, previously associated with fasting levels of plasma insulin and glucose, influences in vivo glucose metabolism and insulin signalling. The primary...
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