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Article

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning.

Protein science : a publication of the Protein Society - 1 Jul 2023

Nguyen Vanessa, Ahler Ethan, Sitko Katherine A, Stephany Jason J, Maly Dustin J, Fowler Douglas M

Abstract excerpt

Hsp90 is a molecular chaperone involved in the refolding and activation of numerous protein substrates referred to as clients. While the molecular determinants of Hsp90 client specificity are poorly understood and limited to a handful of client proteins, strong clients are thought to be destabilized and conformationally extended. Here, we measured the phosphotransferase activity of 3929 variants of the tyrosine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37167432
DOI: 10.1002/pro.4656
PMCID: PMC10273359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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