Article

Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis

2019-06-17

Abstract excerpt

Spermatogonial stem cells (SSCs) both self-renew and give rise to progenitor spermatogonia that enter steady-state spermatogenesis in the mammalian testis. However, questions remain regarding the extent to which SSCs and progenitors represent stably distinct spermatogonial subtypes. Here we provide the first multiparametric integrative analysis of mammalian germ cell epigenomes comparable to that done by the ENCOD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa943427-644a-5928-8511-a7dce73b0521
DOI: 10.1101/674457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse TestisDOI 10.1101/674457Read

Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse TestisSemantic proximity Read

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to SpermatidsSemantic proximity Read

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cellsSemantic proximity Read

TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse TestisSemantic proximity Read

The adult human testis transcriptional cell atlasSemantic proximity Read

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testisSemantic proximity Read

Epigenetic factors in the regulation of prospermatogonia and spermatogonial stem cellsSemantic proximity Read

Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesisSemantic proximity Read

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.Semantic proximity Read

Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitionsSemantic proximity Read

Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencingSemantic proximity Read