Article
A causal relationship between uric acid and diabetic macrovascular disease in Chinese type 2 diabetes patients: A Mendelian randomization analysis.
International journal of cardiology - 1 Jul 2016
Yan Dandan, Wang Jie, Jiang Feng, Zhang Rong, Wang Tao, Wang Shiyun, Peng Danfeng, He Zhen, Chen Haibing, Bao Yuqian, Hu Cheng, Jia Weiping
Abstract excerpt
BACKGROUND: As the association between uric acid and macrovascular disease has been heavily debated, we aimed to confirm whether there is a causal relationship between uric acid and diabetic macrovascular disease through Mendelian randomization analysis. METHODS: In 3207 type 2 diabetes patients, seventeen SNPs (single nucleotide polymorphisms) related to uric acid were genotyped. A weighted GRS (genetic risk...
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